Benign Unconjugated Hyperbilirubinemia

Benign unconjugated hyperbilirubinemia describes a mild and persistent increase in unconjugated (indirect) bilirubin in the blood, without this reflecting liver damage; Gilbert syndrome is its best-known form.

How it is usually noticed: Many people have no discomfort, and sometimes only a subtle yellowish tone is seen in the eyes or skin that becomes more pronounced with fasting, stress, intense exercise, or a passing infection.

Nature of the condition: It tends to be benign in nature and is often detected incidentally in blood tests done for another reason.

Who to consult? The gastroenterologist —in childhood, the pediatric gastroenterology specialist— can assess the finding, distinguish it from other causes of jaundice, and offer reassurance through appropriate follow-up.