Muscle Glycogen Phosphorylase Deficiency

Muscle glycogen phosphorylase deficiency, known as McArdle disease, is a rare inherited metabolic disorder in which the muscle cannot properly use its glycogen reserves as a source of energy during exertion.

Common symptoms: they usually appear during exercise and include early muscle fatigue, pain, cramps, and, at times, exercise intolerance that improves after a brief rest.

Origin: it is due to a genetic alteration that affects an enzyme needed to release energy within the muscle fiber.

Recommended specialist: its evaluation may involve the orthopedist because of the musculoskeletal complaints and the pediatrician when the manifestations begin in childhood, within an approach that usually requires several professionals. If you notice that exercise repeatedly causes you disproportionate muscle pain or exhaustion, the prudent thing is to seek a professional evaluation.