IgG4-Related Systemic Disease

Immunoglobulin G4 (IgG4)-related systemic disease is an uncommon immune disorder in which the defense system causes inflammation and enlargement in various organs, which may include glands, kidneys, pancreas, or other tissues. Because it affects several areas, its evaluation is usually detailed.

Possible manifestations: Inflammation or enlargement of glands, discomfort depending on the organs involved, and, at times, general symptoms such as fatigue.

When to see a doctor? It is reasonable to seek care with persistent inflammation without a clear cause or symptoms that affect several organs at the same time.

Which specialist treats it? Because of its multisystem nature, a team is usually involved: rheumatologist, internist, allergist, nephrologist, and the general practitioner who guides the first visit. With persistent, hard-to-explain symptoms, a professional evaluation is the right path.